E2F6.com-1 Complex: A Protein with Antitumor and Regulatory Functions

Target Name: E2F-6 complex

NCBI ID: P19802

E2F-6 complex

Other Name(s): E2F6.com-1 complex

E2F6.com-1 Complex: A Protein with Antitumor and Regulatory Functions

The E2F-6 complex, also known as E2F6.com-1 complex, is a protein that plays a crucial role in the regulation of gene expression and cell signaling. It is composed of the protein E2F6 and several other non-coding RNAs, and is localized to the nucleus of the cell.

The E2F-6 complex is involved in the process of transcriptional repression, which is the regulation of gene expression. This is accomplished through the interaction of the E2F6 protein with specific DNA sequences, known as response elements, located in the gene's open reading region . The E2F6 protein uses its conserved 伪-helical structure to bind to these response elements and change the binding affinity and stability through changes in base pairs, thereby controlling the expression level of the gene.

In addition, E2F6.com-1 complex also has anti-tumor effects. Studies have shown that E2F6.com-1 complex plays an important role in inhibiting the growth and metastasis of tumor cells.

Due to the key role played by the E2F6.com-1 complex in cell signaling and gene expression, it is considered a potential drug target or biomarker. Currently, researchers are exploring the role of E2F6.com-1 complex in the treatment of various cancers, including breast cancer, lung cancer, prostate cancer, etc.

At the same time, the detection of E2F6.com-1 complex is also widely used in gene expression analysis, RNA binding experiments, gene knockout technology, etc. in biomedical research. For example, by using RNA-seq technology, researchers can detect the expression levels of the E2F6.com-1 complex in cells to understand its impact on gene expression.

Overall, E2F6.com-1 complex is a protein of important biological significance and is of great significance to the study of cell signaling, gene expression, and tumor development. With the deepening of research, E2F6.com-1 complex will bring more hope to medicine.

Protein Name: E2F-6 Complex

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